Investigating the Role of TNF in HIV-1 Infected Cell Death

Authors

Brennan B. Wells, Brigham Young University - ProvoFollow
Sidney Sithole, Brigham Young University - Provo
Bradford Berges, Brigham Young University - ProvoFollow

Files

Keywords

factors influencing HIV cell death

Abstract

HIV-1 is the causative agent of the terminal disease AIDS. Clinical studies have determined that patients infected with a mutant of HIV-1, Vpr-R77Q, do not progress towards AIDS. Subsequently, our lab has discovered two notable differences between the Vpr- R77Q variant and WT HIV-1: increased levels of apoptosis in infected cells (which is thought to contribute to the lack of AIDS progression), and decreased levels of inflammatory cytokines, namely Tumor Necrosis Factor (TNF). The purpose of this ongoing experiment is to investigate the potential inverse correlation between TNF levels and apoptosis levels through the introduction of additional TNF cytokines to an infected system and flow cytometry analysis

BYU ScholarsArchive Citation

Wells, Brennan B.; Sithole, Sidney; and Berges, Bradford, "Investigating the Role of TNF in HIV-1 Infected Cell Death" (2026). Library/Life Sciences Undergraduate Poster Competition 2026. 23.
https://scholarsarchive.byu.edu/library_studentposters_2026/23

Document Type

Poster

Publication Date

2026-03-26

Language

English

College

Life Sciences

Department

Microbiology and Molecular Biology

University Standing at Time of Publication

Freshman

Copyright Use Information

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