Download

Download Full Text (4.8 MB)

Keywords

seizure, ketones, status-epilepticus, MEA, propagate

Abstract

Status epilepticus (SE) is a seizure state characterized by continuous ictal activity lasting over 5 minutes. SE frequently becomes unresponsive to frontline antiepileptic drugs (AEDs), resulting in refractory status epilepticus (RSE), a neurological medical emergency with a mortality rate as high as 38% in some studies. To assess how SE develops over time, we have characterized an ex vivo brain slice SE model using a high-resolution multi-electrode recording system. The system contains over 4000 electrodes with less than 60μM of space in between each electrode. With this unprecedented spatial and temporal resolution, we have identified key features of SE that may help us understand its patterns of propagation as well as possible methods of preventative treatment. Our findings point to SE recruiting tissue and spreading in a modular pattern, with newly recruited regions becoming new ictogenic drivers (ictal cores) of further SE activity.

Document Type

Poster

Publication Date

2026-03-26

Language

English

College

Life Sciences

Department

Exercise Sciences

University Standing at Time of Publication

Junior

Seizure Propagation and How Ketones May Help Mitigate Harmful Effects

Included in

Life Sciences Commons

Share

COinS