Keywords
lncRNA, expression profile, prognostification, somatic copy number alteration
Abstract
Long non-coding RNAs (lncRNAs) have been shown to contribute to tumorigenesis. However, surprisingly little is known about the comprehensive clinical and genomic characterization of lncRNAs across human cancer. In this study, we conducted comprehensive analyses for the expression profile, clinical outcomes, somatic copy number alterations (SCNAs) profile of lncRNAs in ~7000 clinical samples from 15 different cancer types. We identified significantly differentially expressed lncRNAs between tumor and normal tissues from each cancer. Notably, we characterized 47 lncRNAs which were extensively dysregulated in at least 10 cancer types, suggesting a conserved function in cancer development. We also analyzed the associations between lncRNA expressions and patient survival, and identified sets of lncRNAs that possessed significant prognostic values in specific cancer types. Our combined analysis of SCNA data and expression data uncovered 116 dysregulated lncRNAs are strikingly genomic altered across 15 cancer types, indicating their oncogenic potentials. Our study may lay the groundwork for future functional studies of lncRNAs and help facilitate the discovery of novel clinical biomarkers.
Original Publication Citation
Wang ZL, Li B, Piccolo SR, Zhang XQ, Li JH, Zhou H, Yang JH, Qu LH. Integrative analysis reveals clinical phenotypes and oncogenic potentials of long non-coding RNAs across 15 cancer types Oncotarget, 2016 Jun 7;7(23):35044-55. doi:10.18632/oncotarget.9037.
BYU ScholarsArchive Citation
Wang, Ze-Lin; Li, Bin; Piccolo, Stephen R.; Zhang, Xiao-Qin; Li, Jun-Hao; Zhou, Hui; Yang, Jian-Hua; and Qu, Liang-Hu, "Integrative Analysis Reveals Clinical Phenotypes and Oncogenic Potentials of Long Non-coding RNAs Across 15 Cancer Types" (2016). Faculty Publications. 7460.
https://scholarsarchive.byu.edu/facpub/7460
Document Type
Peer-Reviewed Article
Publication Date
2016-04-27
Publisher
Impact Journals
Language
English
College
Life Sciences
Department
Biology
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