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Theses/Dissertations from 2024

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Multifunctional and Moisture Tolerant Zinc-Based Mono- and Bi-metallic Metal-Organic Framework (MOF) thin films, Emmanuel Agbata

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The Generation of Terahertz Light and its Applications in the Study of Vibrational Motion, Aldair Alejandro

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Dissecting Trypanosome Metabolism by Discovering Glycolytic Inhibitors, Drug Targets, and Glycosomal pH Regulation, Daniel Hale Call

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N-H NHC Palladium Catalysts Derived from Unique 2-Phosphinoimidazole Precursors for C-C Cross Coupling Reactions and Application of Slow Releasing Polymers Impregnated With Gibberellic Acid to Overcome Seed Dormancy for Land Reclamation, Alexandra Jean Setelin Larson

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Investigation of Collision Cross Sections & Time-Resolved Structural Modification of Biomolecules, Host-Guest Systems, & Small Molecules Using Ion Mobility & Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Noah Mismash

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DNA-Templated Nanofabrication of Metal-Semiconductor Heterojunctions and Their Electrical Characterization, Chao Pang

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Application and Development of Ceragenins in Medical Device Coatings for Clinical Settings, Elliot E. Sherren

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Computational and Experimental Advances in Nuclear Magnetic Resonance for High Resolution Structures, Ryan Toomey

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Development of Bifunctional Peptides as Scaffolds for Bifunctional Catalysis and a Novel Method of Peptide Stapling Using Squaric Esters, Adam X. Wayment

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Advancing Single-Cell Proteomics Through Innovations in Liquid Chromatography and Mass Spectrometry, Kei Grant Isaac Webber

Theses/Dissertations from 2023

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Developing Genotypic and Phenotypic Systems for Early Analysis of Drug-Resistant Bacteria, Yesman Akuoko

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Monitoring Brain Region-Specific Control of Protein Turnover and Concentration Using Proteomics, Rebecca Suzanne Burlett

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Investigating the Use of Translational Methods to Characterize Therapeutic Interventions in Models of Pulmonary Disease, Ashley Rae Chang

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Separation of Perrhenate and Perfluoroalkyl Substances by Ion Chromatography with Customized Stationary Phases, Wai Ning Chan

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Developing Methods for Measuring in Vivo Lipid Metabolism, Russell L. Denton

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Developing 3D Printed Integrated Microfluidic Devices for Microchip Electrophoresis Separation of Preterm Birth Biomarkers, Joule E. Esene

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Detailed Characterization of Material Deformation, Alexander J. Farnsworth

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Measuring Microparticle Adhesion via High-Speed Rotor, Jacob C. Fearnley

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Characterization of TELSAM Chaperone Linker to Improve Crystallization Resolution and Structural Elucidation of the Hydrogenase Maturase Complex, Parag Laljibhai Gajjar

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The Role of Cytosolic Chaperonin CCT and its Co-Chaperone PhLP1 in Folding and Assembly of Signaling Complexes, Yujin Kwon

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Use and Misuse of X-Ray Photoelectron Spectroscopy (XPS): Reproducibility, Gross Errors, Data Reporting, and Peak Fitting, George Hobbs Major

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Exploring Surface Silanization and Characterization of Thin Films: From Surface Passivation to Microstructural Characterization of Porous Silicon/Silica, and Exploratory Data Analysis of X-Ray Photoelectron Spectroscopy Images, Behnam Moeini

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Terahertz from Electrons, Electronics from Terahertz, Clayton D. Moss

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Progress Towards the Development of Asymmetric Conditions for Intramolecular Heteroatom/Dehydro-Diels-Alder Reactions for Synthesizing Furo[3,4-c] Pyranones and Anticancer Podophyllotoxins, Peter Mpaata

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Developing Microfluidic Devices for Biomolecule Analysis, Jacob Brent Nielsen

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Navigating Molecular Complexity: A Multidimensional Approach Utilizing Computational Chemistry, Jacob Andrew Parkman

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Synthesis of Yaku'amide A Analogues and Progress Toward Synthesis of Virosine A, Alexander S. Ramos

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Soft Contact Lens Tear Film Proteomics for Clinical Diagnostic Biomarker Discovery, Robert Kimball Roden

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Exploring New Horizons in Microwave-Promoted Iminyl Radical Chemistry and Synthesis of Bulky Dehydroamino Acids, Jatinder Singh

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Role of the Cytosolic Chaperonin CCT in the Folding of Novel Substrates, Theresa M. Smith

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Context Dependence of Non-Covalent Interactions Among Amino-Acid Side Chains Along the Solvent-Exposed Surface of Coiled Coils, Kimberlee Larsen Stern

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Design, Synthesis and Immunological Testing of Minimal Oligosaccharide Epitopes for Glycoconjugate Vaccines Targeting Capsular Polysaccharides of Serotypes 3, 4, 7F and 9V of Streptococcus Pneumoniae, Seth A. Taylor

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A Step into Structural Biology: Structural Determination of TNK1-UBA and Computational Design of a Radical SAM Cyclase, Yi-Jie Tseng

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Undergraduate Students' Conceptions of NGSS Science and Engineering Practices, Jessie Webb

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Interfacial Properties of Hybrid Lipid-Polymer Bilayers: Applications in Drug Delivery and Biosensors, Keith L. Willes

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Using Quantitative and Kinetic Proteomics to Explore Proteostasis, Nathan Raul Zuniga Pina

Theses/Dissertations from 2022

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Developing the Next Generation of Heterogeneous Catalysts: Metal-Organic Framework Thin Films and Their Derivatives, Hans Christian Anderson

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Gas Phase Techniques for the Study of Biomolecular and Supramolecular Structures and Chemistry, Andrew J. Arslanian

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Identification of Sources of Air Pollution Using Novel Analytical Techniques and Instruments, Nitish Bhardwaj

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Quantifying Volatile Fatty Acid Concentrations During the Pretreatment and Anaerobic Digestion Process, Sascha Boutelle

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Computational Studies of Dinuclear Catalytic Reaction Mechanisms, James Curtis Coombs III

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Synthesis and Anticancer Evaluation of Novel Pyrazolo[1,5-a]pyrimidines: Discovery of a Novel Lead Compound with Selective Activities Against VPS34 and JAK1-JH2 Pseudokinase, Reuben Dass

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Determination of a Catalytic Mechanism by Time Resolved Fourier Transform Infrared Spectroscopy and Time Domain Analysis of Data from Fourier Transform Ion Cyclotron Resonance Mass Spectrometry, Jacob T. Davis

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Experimental Design and Construction of the First Rotor Induced Collision Cell (RICC) for Studying High Velocity Molecular Impacts, Abraham Lehi De la Cruz Hernandez

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Examination of 14-3-3 Interactors Identifies a Novel Mechanism of Regulation for the Ubiquitin Binding Kinase TNK1 That Can Be Targeted to Block Tumor Growth, Christina Marie Egbert

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Understanding the Complexities of Anemia in Chronic Inflammatory Diseases from Diagnosis to Treatment, Naomi Rae Flindt

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Development of Cooperative Catalytic Systems and Bimetallic Catalysts for Organic Synthesis, Kelton Guy Forson

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Design and Evaluation of Miniaturized Ion Trap Mass Analyzers Using Simulation, Radhya Weligama Gamage

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Atomic Layer Deposition and High Sensitivity-Low Energy Ion Scattering for the Determination of the Surface Silanol Density on Glass and Unsupervised Exploratory Data Analysis with Summary Statistics and Other Methods, Tahereh Gholian Avval

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Charge Detection Mass Spectrometry Using Printed Circuit Board Arrays for the Analysis of Microparticles in the Martian Atmosphere, Elaura LuAnne Gustafson

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Ion Structure Characterization and Energetics in the Gas Phase Using Fourier Transform Ion Cyclotron Resonance Mass Spectrometry and Ion Mobility Spectrometry, Tina Heravi

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Synthesis of Yaku’amide A Analogues and Impact of Dehydroamino Acids on the Structure and Stability of Incipient 310 Helical Peptides, Daniel Joaquin

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Inhibition of Cell Adhesion and Actin Localization During Migration Upon Protective Antigen Mutant Ligand Binding to the Capillary Morphogenesis Gene 2, Sai Lun Lee

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Methods for Single-Cell and Low-Input Proteomics, Yiran Liang

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Quantifying Protein Quality to Understand Protein Homeostasis, Hsien-Jung Lavender Lin

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A Machine Learning Approach that Integrates Clinical Data and PTM Proteomics Identifies a Mechanism of ACK1 Activation and Stabilization in Cancer, Eranga Roshan Balasooriya Loku Balasooriyage

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The Discovery of Novel 14-3-3 Binding Proteins ATG9A and PTOV1 and Their Role in Regulating Cancer Mechanisms, Colten Mitchell McEwan

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Synthesis and Applications of α,β-Dehydroamino Acid-Containing Peptides, Diego A. Moya

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ATG9A and ATG13 Cooperate to Drive Basal Autophagy, Daniel Morgan Poole

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Material Characterization Using Nuclear Magnetic Resonance, Giovanna Marcella Pope

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Fabrication and Characterization of DNA Templated Electronic Nanomaterials and Their Directed Placement by Self-Assembly of Block Copolymers, Dulashani Ruwanthika Ranasinghe Weerakkodige

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The Novel Protein Crystallization Chaperone TELSAM Stabilizes Weak Crystal Contacts, Accelerates Crystallization of Fused Target Proteins, and Solves the Crystallographic Phase Problem, Supeshala Dilrukshi Sarath Nawarathnage

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Gas Phase Structure Characterization of Host-Guest Systems Using Ion Mobility Spectrometry, Jamir Shrestha

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The TELSAM Protein Polymer Significantly Improves the Speed and Propensity of Crystallization of Target Proteins, Seyedeh Sara Soleimani

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High-Velocity Impact Dissociation of Molecular Species in Spacecraft-Based Mass Spectrometers, Brandon M. Turner

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Hybrid Suspension Tissue Engineering of a 3D Alveolar Model for Lung and Vascular Disease Modeling, Jonard Corpuz Valdoz

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Computationally Assisted NMR Crystallography: A Path to Unusually High-Resolution Crystal Structures, Luther Wang

Theses/Dissertations from 2021

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Immunoaffinity Monoliths for Multiplexed Extraction of Preterm Birth Biomarkers from Human Blood Serum in 3D Printed Microfluidic Devices, Haifa Mohammad Almughamsi

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Bottom-Up Fabrication and Characterization of DNA Origami-Templated Electronic Nanomaterials, Basu Ram Aryal

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The Mechanism of PTOV1 Regulation by 14-3-3, HUWEI1 and SGK2, Pramoda Sahan Kumari Aththota Gamage

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Molecular Dynamics of Organometallic Systems, Ryan Wayne Carlsen

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PEGylation Stabilizes the Conformation of Proteins and the Noncovalent Interactions Within Them, Steven R. E. Draper

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Going for Gold: Point of Care Bio-Diagnostics and Gold Nanoparticles Treating Disease, Trevor M. Godfrey

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Sequence Specific Concentration and Labeling of Bacterial Plasmids for Future Use in Detection of Drug-Resistant Sepsis Cases Without Amplification, Robert L. Hanson

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Cationic Steroid Antimicrobials: Applications to Medical Device Coatings, Mechanism of Pro-Osteogenic Properties, and Potential Synergy with Common Antifungals, Brian J. Hilton

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Nonlinear Ultrafast Excitation and Two-Dimensional Terahertz Spectroscopy of Solids, Brittany E. Knighton

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Microwave-Promoted Iminyl Radical Fragmentations and the Total Synthesis of Yaku'amide A and its Simplified Analogues, Concordia Lo

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The Role of the Cytosolic Chaperonin CCT in Folding β-Propeller Proteins, William Grant Ludlam

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2-Phosphinoimidazole Derived Monometallic and Bimetallic Catalysts, Erin Martinez

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Fabrication of Advanced Materials for Chromatography, Sample Preparation, and Separations, and Accompanying Material Characterization, Dhananjay I. Patel

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Non-Linear Optical Characterization of Stressed Materials, Kaylee N. Rellaford

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Electrocatalytic Oxidation of Carbohydrates Via Surface Immobilized Viologen, Dallin D.V. Scott

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Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidines and (4-Hydroxy-6-trifluoromethylpyrimidin-2-yl) guanidines, Justin Dave Singleton

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Synthesis and Utility of Chiral and Achiral Trifluoroacetamide Substrates in Cycloaddition Reactions, Isaac Theodore Smith

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Galectin-1: Development of a Novel Protein Therapy for LGMD2B, Mary Lorena Vallecillo Munguia

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Protein Conformational Stability Enhancement Through PEGylation and Macrocyclization, Qiang Xiao

Theses/Dissertations from 2020

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Microfabricated Fluidic Devices for Biological Assays and Bioelectronics, Anna V. Bickham

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Discovery of a Novel Regulatory Mechanism of TNK1 by 14-3-3 and Its Ubiquitin Association Domain Provides a Potential Therapeutic Targeting Opportunity in Cancer, Tsz Yin Chan

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Organic Synthesis using Bimetallic Catalysis, Chloe Christine Ence

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Instrumentation and Application of Image-Charge Detection of Electrospray-Charged Microparticles and Microdroplets, Jiuzhi Gao

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Synthesis of Functionalized Streptococcus pneumoniae Serotype 6A Di- and Tri- Saccharides, Brady Davis James

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An ULK1-Independent Mechanism of ATG9A Regulation in Basal Autophagy, Ashari Rashmi Kannangara

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Breaking the Organic Mold: Introducing Copper into the Influenza A Arena with Neutral and Divalent Complexes, Jonathan D. Lynch

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Galectin-1 Improves Sarcolemma Repair and Decreases the Inflammatory Response in LGMD2B Models, Matthew F. Rathgeber

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Thin Film Deposition on Powder Substrates using ALD and its Characterization using XPS, TEM, and SE, Dhruv Shah

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Structures and Characteristics of Macromolecular Interactions in Gas Phase Using Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry, Jiewen Shen

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The Role of the Chaperone CCT in Assembling Cell Signaling Complexes, Nicole C. Tensmeyer

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Capillary Morphogenesis Gene Protein 2 (CMG2) Mediates Matrix Protein Uptake and is Required for Endothelial Cell Chemotaxis in Response to Multiple Vascular Growth Factors, Tsz Ming Jeremy Tsang

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Design, Synthesis, and Characterization of New Non-Centrosymmetric Organic Crystals for Terahertz Generation, Gabriel Alejandro Valdivia-Berroeta

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Novel αvβ6 Inhibitor Reduces Fibrotic Progression in Idiopathic Pulmonary Fibrosis Murine Model, Rebecca C. Viazzo Winegar