CD6-Knockout CAR-T Cells Display Enhanced Cytotoxicity Against Lymphoma Cell Line

Authors

Annie Larson, Brigham Young University - ProvoFollow
Alka Gaur, Brigham Young University - Provo
Nate Neyman, Brigham Young University - Provo
Collin Mickelson, Brigham Young University - Provo
K. Scott Weber, Brigham Young University - ProvoFollow

Files

Keywords

CAR-T cell, cancer immunotherapy, CD6

Abstract

Chimeric antigen receptor (CAR)-T cells are genetically engineered T cells that target surface antigens on cancer cells, showing remarkable effectiveness in treating blood cancers [1]. However, CAR-T cells are currently not effective in treating solid tumors, as the tumor microenvironment poses physical and metabolic barriers to effective CAR-T cell function. A notable strategy for increasing CAR-T cell cytotoxicity in a tumor microenvironment is knocking out or overexpressing some genes of the T cell.

BYU ScholarsArchive Citation

Larson, Annie; Gaur, Alka; Neyman, Nate; Mickelson, Collin; and Weber, K. Scott, "CD6-Knockout CAR-T Cells Display Enhanced Cytotoxicity Against Lymphoma Cell Line" (2026). Library/Life Sciences Undergraduate Poster Competition 2026. 43.
https://scholarsarchive.byu.edu/library_studentposters_2026/43

Document Type

Poster

Publication Date

2026-03-26

Language

English

College

Life Sciences

Department

Microbiology and Molecular Biology

University Standing at Time of Publication

Senior

Copyright Use Information

https://lib.byu.edu/about/copyright/