Enhancing Metabolic Fitness of CAR T-Cells by Removing CD6

Authors

Nate Neyman, Brigham Young University - ProvoFollow
Alka Guar, Brigham Young University - Provo
Annie Joy-Larson, Brigham Young University - Provo
Collin Mickelson, Brigham Young University - Provo
Scott Weber, Brigham Young University - ProvoFollow

Files

Keywords

CAR T-cell therapy, cancer immunotherapy, CAR T-cell metabolism, CD6 signaling, solid tumors

Abstract

Honorable Mention - Poster Design

CAR T-cell therapy is a highly effective cancer treatment involving engineering the patient’s T-cells to recognize and kill cancerous cells. This therapy has shown great success for blood cancers but has faced many challenges against solid tumors.

Surrounding tumor cells there is a lack of essential nutrients (oxygen, glucose) for T-cells to metabolize efficiency. Additionally, there is a buildup of excess waste products that directly impair T-cell function (1). To overcome these obstacles, scientists are working on developing longer lasting T-cells with improved metabolism to improve efficacy against cancer cells.

BYU ScholarsArchive Citation

Neyman, Nate; Guar, Alka; Joy-Larson, Annie; Mickelson, Collin; and Weber, Scott, "Enhancing Metabolic Fitness of CAR T-Cells by Removing CD6" (2026). Library/Life Sciences Undergraduate Poster Competition 2026. 32.
https://scholarsarchive.byu.edu/library_studentposters_2026/32

Document Type

Poster

Publication Date

2026-03-26

Language

English

College

Life Sciences

Department

Public Health

University Standing at Time of Publication

Junior

Copyright Use Information

https://lib.byu.edu/about/copyright/