Using Chimeric autoantigen receptor (CAAR) T cells to eliminate autoreactive B cells in autoimmune diseases

Authors

Abigail Cheever, Brigham Young University - Provo
Chloe Kang, Brigham Young University - ProvoFollow
Hunter Lindsey, Brigham Young University - Provo
Mackenzie Hansen, Brigham Young University - Provo
Kim O'Neill, Brigham Young University - Provo
Scott Weber, Brigham Young University - ProvoFollow

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Keywords

Immunology, Autoimmune disease, Cancer prevention, CAR T cells

Abstract

• Graves’ disease (GD) is an antibody-mediated autoimmune disease affecting the thyroid and causes hyperthyroidism
• 4th most common autoimmune disease in the US
• Autoreactive B cells produce anti-TSHR antibodies (TRAbs) which mimic thyroid stimulating hormone (TSH) and chronically stimulate thyroid cells causing hyperthyroidism
• There currently is no treatment which addresses the root cause of the disease

BYU ScholarsArchive Citation

Cheever, Abigail; Kang, Chloe; Lindsey, Hunter; Hansen, Mackenzie; O'Neill, Kim; and Weber, Scott, "Using Chimeric autoantigen receptor (CAAR) T cells to eliminate autoreactive B cells in autoimmune diseases" (2024). Library/Life Sciences Undergraduate Poster Competition 2024. 67.
https://scholarsarchive.byu.edu/library_studentposters_2024/67

Document Type

Poster

Publication Date

2024-03-21

Language

English

College

Life Sciences

Department

Biology

University Standing at Time of Publication

Junior

Copyright Use Information

https://lib.byu.edu/about/copyright/