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Keywords

Cell Death, Inflammation, and Extracellular Vpr in the R77Q Mutation of Vpr in HIV-1

Abstract

One potential target for therapeutic treatment of HIV-1 is Viral Protein R (Vpr), an accessory protein encoded by the HIV-1 genome. Vpr plays an important role in pathogenesis and replication for HIV and is involved in transcription, the pre-integration complex, cell cycle arrest, and cell death via apoptosis. Mutations in this protein dramatically impact the rate of AIDS progression compared to the wild type (WT) version of Vpr. The Vpr polymorphism R77Q is associated with the Long Term Non Progressor (LTNP) phenotype. Regular AIDS onset is 5-7 years for WT virus and 10 or more years for R77Q. These differences in AIDS progression have been observed in vivo by following people with HIV over time.

Document Type

Poster

Publication Date

2024-03-21

Language

English

College

Life Sciences

Department

Microbiology and Molecular Biology

University Standing at Time of Publication

Senior

Cell Death, Inflammation, and Extracellular Vpr in the R77Q Mutation of Vpr in HIV-1

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