BYU ScholarsArchive

Title

Exploration of the Mechanisms Underlying Cortical Spreading Depolarizations Associated with Familial Hemiplegic Migraines

Authors

Brit Hepworth, Brigham Young University - ProvoFollow
Ryley Parrish, Brigham Young University - Provo

Files

Keywords

Methods, Microscopy, Two-Photon, Iontophoresis

Abstract

Cortical Spreading Depolarization (CSD) - wave of cellular depolarization followed by wave of depression/inhibition • Familial Hemiplegic Migraine (FHM3) - monogenic subtype of migraine with aura; caused by Scn1A mutation, leading to gain-of-function of Nav1.1 (voltage gated sodium channel) • Hm1a - compound which potentiates the persistent current in Nav1.1; mimics the Scn1A gain-of-function mutation observed in patients with FHM3 • It is commonly hypothesized that CSDs are triggered via raised extracellular potassium, threshold for induction ~12mM • Modifications of Hm1a compound in development for treatment of Dravet Syndrome, but has been shown in a few cases to induce CSDs.

BYU ScholarsArchive Citation

Hepworth, Brit and Parrish, Ryley, "Exploration of the Mechanisms Underlying Cortical Spreading Depolarizations Associated with Familial Hemiplegic Migraines" (2023). Library/Life Sciences Undergraduate Poster Competition 2023. 46.
https://scholarsarchive.byu.edu/library_studentposters_2023/46

Document Type

Poster

Publication Date

2023-02-28

Language

English

College

Life Sciences

Department

Cell Biology and Physiology

University Standing at Time of Publication

Junior

Copyright Use Information

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