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Claudin, Neural Tube Defects, Tight Junction
Claudins (CLDN), a family of proteins found in the tight junction, play a major role in membrane permeability. While claudin disruption is known to contribute to the formation of neural tube defects (NTD), current research methods rely heavily on a non-specific toxin, CPE, when exploring the importance of CLDNs within neural tube formation. This makes it difficult to identify individual CLDN’s contribution to NTD formation, creating a need for a more specific method.
BYU ScholarsArchive Citation
Allen, Wesley; Beckett, Nathan; Brenchley, Emma; Wengler, Jacob; Hall, Lauren; Winn, Cailey; Mann, Meredith; Jung, Sion; Thacker, Spencer; May, Rachel; Mizrachi, Dario; and Stark, Micheal, "Chimeric claudins reveal role in neural tube defects" (2022). Library/Life Sciences Undergraduate Poster Competition 2022. 14.
Cell Biology and Physiology
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