BYU ScholarsArchive

Title

Chimeric claudins reveal role in neural tube defects

Authors

Wesley Allen, Brigham Young University - ProvoFollow
Nathan Beckett, Brigham Young University - Provo
Emma Brenchley, Brigham Young University - Provo
Jacob Wengler, Brigham Young University - Provo
Lauren Hall, Brigham Young University - Provo
Cailey Winn, Brigham Young University - Provo
Meredith Mann, Brigham Young University - Provo
Sion Jung, Brigham Young University - Provo
Spencer Thacker, Brigham Young University - Provo
Rachel May, Brigham Young University - Provo
Dario Mizrachi, Brigham Young University - Provo
Micheal Stark, Brigham Young University - Provo

Files

Keywords

Claudin, Neural Tube Defects, Tight Junction

Abstract

Claudins (CLDN), a family of proteins found in the tight junction, play a major role in membrane permeability. While claudin disruption is known to contribute to the formation of neural tube defects (NTD), current research methods rely heavily on a non-specific toxin, CPE, when exploring the importance of CLDNs within neural tube formation. This makes it difficult to identify individual CLDN’s contribution to NTD formation, creating a need for a more specific method.

BYU ScholarsArchive Citation

Allen, Wesley; Beckett, Nathan; Brenchley, Emma; Wengler, Jacob; Hall, Lauren; Winn, Cailey; Mann, Meredith; Jung, Sion; Thacker, Spencer; May, Rachel; Mizrachi, Dario; and Stark, Micheal, "Chimeric claudins reveal role in neural tube defects" (2022). Library/Life Sciences Undergraduate Poster Competition 2022. 14.
https://scholarsarchive.byu.edu/library_studentposters_2022/14

Document Type

Poster

Publication Date

2022-3

Language

English

College

Life Sciences

Department

Cell Biology and Physiology

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