Exploring the Mechanism of “Forgetting” with Electrophysiology

Title

Exploring the Mechanism of “Forgetting” with Electrophysiology

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Keywords

synaptic plasticity, depotentiation

Abstract

Background

  • An estimated six million Americans suffer from neurological disorders such as Alzheimer's and Dementia (Alzheimer's Association, 2021). Studying the brain in the context of synaptic plasticity, or how the brain changes and adapts, can shed new light on the effects of aging and these forgetting disorders.
  • Long-term potentiation is the strengthening of synapses and is correlated with learning and memory. Depotentiation is the weakening of synapses and is correlated with “forgetting." Understanding these two opposing processes may be helpful in learning more about the inner workings of the brain.
  • There are several factors that may affect depotentiation, including the age of the brain, the types of neuronal membrane receptors involved, and the duration of LTP prior to depotentiation. Using electrophysiology, we are investigating the role these factors play in "forgetting.”

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Document Type

Video

Publication Date

2021

Language

English

College

Life Sciences

Department

Physiology and Developmental Biology

University Standing at Time of Publication

Senior

Exploring the Mechanism of “Forgetting” with Electrophysiology

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