Keywords

eLiposome, drug delivery, liposome, ultrasound, perfluorocarbon emulsion

Abstract

A novel nanosized liposomal carrier was prepared consisting of perfluorocarbon emulsion droplet(s) encapsulated inside a liposome, which is called an eLiposome. This 200-nm construct is useful for acoustically activated drug delivery because ultrasound causes the emulsion droplet to expand from liquid to gas, which expansion ruptures the eLiposome bilayer and releases the internal contents. This study focuses on the parameters that influence control of the release of calcein (a model drug), including ultrasound amplitude, insonation time, and perfluorocarbon vapor pressure as a function of temperature and composition. The results show that calcein release increases as the ultrasound amplitude or insonation time increases. Changing the composition of emulsion droplets from perfluorohexane to perfluoropentane increases release, as does increasing temperature. The release of calcein increases as the droplet vapor pressure increases, but the correlation with vapor pressure does not appear to be strictly linear.

Original Publication Citation

https://doi.org/10.33263/LIANBS41.251258