Keywords

Ultrasound, Drug Delivery, Liposomes, Doxorubicin, BDIX Rats, Rumor Model

Abstract

Ultrasound is a convenient trigger for site-specific drug delivery in cancer therapy. Nanosized liposomes formulated from soy phosphatidyl choline, cholesterol, 1,2-distearoyl-sn-glycero3-phosphoethanolamine-N-[carboxy(polyethylene glycol)-2000] and alpha-tocopherol were loaded with Doxorubicin (Dox)using a pH gradient. The liposomal suspension was infused through the tail vein of BDIX rats possessing bilateral intradermal DHD/K12 tumors on their hind legs. Then 20-kHz ultrasound was applied to only one of the tumors for 15 minutes. This therapy was repeated weekly for 4 weeks. The results showed that in five of sixrats, the tumors regressed to non-measurable size within 4 weeks. A paired comparison of the normalized size of the insonated and non-insonated tumors in the same rat indicated that the insonated tumors were smaller (p < 00001, n = 6 rats, 21 pairs). This observation has significant potential for non-invasive site-specific therapy of solid tumors.

Original Publication Citation

Pitt, W. G., Husseini, G. A., Roeder, B. L., Dickinson, D., Warden, D., Hartley, J., & Jones, P. (2010). Preliminary results of combining low frequency low intensity ultrasound and liposomal drug delivery to treat tumors in rats. Nanoscience and Nanotechnology, 10, 1-5., doi:10.1166/jnn.2010.3117

Document Type

Peer-Reviewed Article

Publication Date

2010-03-23

Publisher

American Scientific Publishers

Language

English

College

Ira A. Fulton College of Engineering

Department

Chemical Engineering

University Standing at Time of Publication

Full Professor

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