Hypoxanthine Guanine Phosphoribosyltransferase Expression is Negatively Correlated with Immune Activity through its Regulation of Purine Synthesis

Authors

Michelle H. Townsend, Brigham Young University - ProvoFollow
Claudia M. Tellez Freitas, Brigham Young University - Provo
Dallas Larsen, Brigham Young University - Provo
Stephen R. Piccolo, Brigham Young University - Provo
K. Scott Weber, Brigham Young University - Provo
Richard A. Robison, Brigham Young University - Provo
Kim L. O’Neill, Brigham Young University - Provo

Keywords

Hypoxanthine Guanine Phosphoribosyltransferase (HPRT or HPRT1)AdenosineImmune infiltration

Abstract

The purpose of this study was to examine the effects of elevated Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) on the immune response in the tumor microenvironment.

Original Publication Citation

Townsend MH, Tellez Freitas CM, Larsen D†, Piccolo SR, Weber KS, Robison RA, and O’Neill KA. Hypoxanthine Guanine Phosphoribosyltransferase expression is negatively correlated with immune activity through its regulation of purine synthesis. Immunobiology, 2020

BYU ScholarsArchive Citation

Townsend, Michelle H.; Tellez Freitas, Claudia M.; Larsen, Dallas; Piccolo, Stephen R.; Weber, K. Scott; Robison, Richard A.; and O’Neill, Kim L., "Hypoxanthine Guanine Phosphoribosyltransferase Expression is Negatively Correlated with Immune Activity through its Regulation of Purine Synthesis" (2020). Faculty Publications. 7487.
https://scholarsarchive.byu.edu/facpub/7487

Document Type

Peer-Reviewed Article

Publication Date

2020-5

Publisher

Elsevier

Language

English

College

Life Sciences

Department

Biology

University Standing at Time of Publication

Associate Professor

Copyright Use Information

https://lib.byu.edu/about/copyright/