Keywords

inhaler, PTF, PTP, rabbit, voice

Abstract

Objectives: This study examined the effects of a combination corticosteroid plus long-acting beta2-adrenergic agonist inhaler (IC) on rabbit phonation. Methods: White New Zealand male rabbits were assigned randomly to experimental and control groups (n = 11 per group). The experimental group received twice-daily doses of Advair HFA™ (fluticasone propionate 45 mcg and salmeterol 21 mcg) via a veterinary facemask with 1-way valve and spacer; the control group received aerosolized saline. After 8 weeks, animals were euthanized, larynges excised, frozen, and subsequently thawed and mounted on a standard bench apparatus. Phonation was elicited during 15 successive trials, and phonation threshold pressure (PTP; cmH2O) and flow (PTF; L/min) were quantified. Results: Repeated measures analysis of variance indicated significant differences between the experimental and control groups (p < 0.05). Mean PTP and PTF values were higher (worse) for rabbits that received Advair HFA™. Conclusion: Following 8-week exposure to ICs, rabbit larynges required greater air pressure and flow to initiate phonation. Because even modest phonation onset differences can have a meaningful clinical impact on voice function, these findings suggest that LABA ICs may put patients at risk for voice disorders. Furthermore, these voice disorders may occur within a relatively short timeframe. The results from this study have important clinical implications for voice care in those who use ICs.

Original Publication Citation

Tanner, K., Robison, H.J., Stevens, M.E., Merrill, R.M., Dromey, C., Barkmeier-Kraemer, J., & Christensen, M.B. (2023) Corticosteroid-LABA inhalers increase phonation threshold pressure (PTP) and flow (PTF) in rabbits. The Laryngoscope, 133, 2680-2686

Document Type

Peer-Reviewed Article

Publication Date

2023

Publisher

The American Laryngological, Rhinological and Otological Society, Inc.

Language

English

College

David O. McKay School of Education

Department

Communication Disorders

University Standing at Time of Publication

Full Professor

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