Covariance and correlation, Genomics, Probability theory, Interpolation, Hydrodynamics simulations, Polymer solution flows, Monte Carlo methods, Nanochannels, Crankshafts, Computer simulation
Using Monte Carlo simulations of a touching-bead model of double-stranded DNA, we show that DNA extension is enhanced in isosceles triangular nanochannels (relative to a circular nanochannel of the same effective size) due to entropic depletion in the channel corners. The extent of the enhanced extension depends non-monotonically on both the accessible area of the nanochannel and the apex angle of the triangle. We also develop a metric to quantify the extent of entropic depletion, thereby collapsing the extension data for circular, square, and various triangular nanochannels onto a single master curve for channel sizes in the transition between the Odijk and de Gennes regimes.
Original Publication Citation
Biomicrofluidics 7, 024102 (2013); https://doi.org/10.1063/1.4794371
BYU ScholarsArchive Citation
Reinhart, Wesley F.; Tree, Douglas R.; and Dorfman, Kevin D., "Entropic depletion of DNA in triangular nanochannels" (2013). Faculty Publications. 6290.
American Institute of Physics
Ira A. Fulton College of Engineering
© 2013 American Institute of Physics.
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