"Entropic depletion of DNA in triangular nanochannels" by Wesley F. Reinhart, Douglas R. Tree et al.
 

Keywords

Covariance and correlation, Genomics, Probability theory, Interpolation, Hydrodynamics simulations, Polymer solution flows, Monte Carlo methods, Nanochannels, Crankshafts, Computer simulation

Abstract

Using Monte Carlo simulations of a touching-bead model of double-stranded DNA, we show that DNA extension is enhanced in isosceles triangular nanochannels (relative to a circular nanochannel of the same effective size) due to entropic depletion in the channel corners. The extent of the enhanced extension depends non-monotonically on both the accessible area of the nanochannel and the apex angle of the triangle. We also develop a metric to quantify the extent of entropic depletion, thereby collapsing the extension data for circular, square, and various triangular nanochannels onto a single master curve for channel sizes in the transition between the Odijk and de Gennes regimes.

Original Publication Citation

Biomicrofluidics 7, 024102 (2013); https://doi.org/10.1063/1.4794371

Document Type

Peer-Reviewed Article

Publication Date

2013-03-01

Publisher

American Institute of Physics

Language

English

College

Ira A. Fulton College of Engineering

Department

Chemical Engineering

University Standing at Time of Publication

Assistant Professor

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