Abstract
DNA confinement in nanochannels is emerging as an important tool for genomics and an excellent platform for testing the theories of confined wormlike polymers. Using cutting-edge, large scale Monte Carlo simulations of asymptotically long wormlike chains, we show that, in analogy to the rod-to-coil transition for free wormlike polymers, there exists a universal, Gauss–de Gennes regime that connects the classic Odijk and de Gennes regimes of channel-confined chains. For DNA in a nanochannel, this Gauss–de Gennes regime spans practically the entire experimentally relevant range of channel sizes, including the nanochannels used in an incipient genome mapping technology.
Original Publication Citation
10.1103/PhysRevLett.110.208103
BYU ScholarsArchive Citation
Tree, Douglas R.; Wang, Yanwei; and Dorfman, Kevin D., "Extension of DNA in a Nanochannel as a Rod-to-Coil Transition" (2013). Faculty Publications. 6281.
https://scholarsarchive.byu.edu/facpub/6281
Document Type
Peer-Reviewed Article
Publication Date
2013-05-13
Publisher
American Physical Society
Language
English
College
Ira A. Fulton College of Engineering
Department
Chemical Engineering
Copyright Status
©2013 American Physical Society.
Copyright Use Information
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