Keywords

SIENA, injury severity, brain volume change

Abstract

Neuropathological and experimental animal studies indicate that traumatic brain injury (TBI) results in long-term, neurodegenerative changes. Structural image evaluation using normalization of atrophy (SIENA) offers an automated analysis of the subtle changes in percent brain volume change (%BVC) associated with TBI. In the present study, SIENA was used to evaluate %BVC in individuals who had sustained a mild to severe TBI. We obtained 3D-T1 weighted anatomical MRI scans approximately 79 days and again 409 days post-injury. TBI patients (n= 37) displayed significantly greater decline in %BVC (-1.43%) relative to a normal comparison group (+ 0.1%, n=30). Greater %BVC was associated with longer duration of post-injury coma. These results confirm previous findings from cross-sectional studies, and suggest that the brain undergoes structural changes for several months after TBI.

Original Publication Citation

Trivedi, Mehul A., et al. "Longitudinal Changes in Global Brain Volume between 79 and 409 Days After Traumatic Brain Injury: Relationship with Duration of Coma." Journal of Neurotrauma, vol. 24, no. 5, 2007, pp. 766-771, https://doi.org/10.1089/neu.2006.0205, doi:10.1089/neu.2006.0205.

Document Type

Peer-Reviewed Article

Publication Date

2009-01-16

Publisher

National Institutes of Health

Language

English

College

Family, Home, and Social Sciences

Department

Psychology

University Standing at Time of Publication

Associate Professor

Included in

Psychology Commons

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