Keywords

Helicobacter pylori, cognition, inflammation, folate, C-reactive protein, ferritin.

Abstract

Background: Helicobacter pylori(H. pylori) infection is associated with cogni-tive deficits in humans, an association potentially mediated or moderated byfolate concentration or inflammation.Materials and

Methods: We used the National Health and Nutrition Exami-nation Survey (NHANES) datasets to examine whether folate concentrationor inflammation mediates or moderates the relationship betweenH. pyloriand cognitive function. Models were performed using linear, Poisson, andzero-inflated Poisson regression, and we performed separate analyses forgroups aged 20–59 and 60–90 years with sample sizes ranging from 700 to1700.Results:We did not find evidence of mediation in either age group. In the20- to 59-year group, interactions betweenH. pyloriand ferritin (pvaluesranging from .004 to .039) were associated with worse processing speed,better working memory, and worse reaction time. Interactions betweenH. pyloriand fibrinogen (pvalues ranging from .023 to .045), C-reactive pro-tein (CRP) (p=.023), and the inflammatory index (p=.045) were associ-ated with worse processing speed. In 60- to 90-year-olds,H. pyloriinteractedwith ferritin and the inflammatory index to predict fewer mathematicalerrors (pvalues of .036 and .023). Interactions with folate (pvalues of .016and .006) and C-reactive protein (pvalues ranging from<.001 to .048) wereinconsistent in directionality.

Conclusions: In this dataset, representative of the US population, inflamma-tion and folate concentrations moderated but did not mediate the associationbetweenH. pyloriseropositivity and cognition.

Document Type

Peer-Reviewed Article

Publication Date

2016

Publisher

John Wiley & Sons Ltd

Language

English

College

Family, Home, and Social Sciences

Department

Psychology

Included in

Psychology Commons

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