Keywords
Helicobacter pylori, cognition, inflammation, folate, C-reactive protein, ferritin.
Abstract
Background: Helicobacter pylori(H. pylori) infection is associated with cogni-tive deficits in humans, an association potentially mediated or moderated byfolate concentration or inflammation.Materials and
Methods: We used the National Health and Nutrition Exami-nation Survey (NHANES) datasets to examine whether folate concentrationor inflammation mediates or moderates the relationship betweenH. pyloriand cognitive function. Models were performed using linear, Poisson, andzero-inflated Poisson regression, and we performed separate analyses forgroups aged 20–59 and 60–90 years with sample sizes ranging from 700 to1700.Results:We did not find evidence of mediation in either age group. In the20- to 59-year group, interactions betweenH. pyloriand ferritin (pvaluesranging from .004 to .039) were associated with worse processing speed,better working memory, and worse reaction time. Interactions betweenH. pyloriand fibrinogen (pvalues ranging from .023 to .045), C-reactive pro-tein (CRP) (p=.023), and the inflammatory index (p=.045) were associ-ated with worse processing speed. In 60- to 90-year-olds,H. pyloriinteractedwith ferritin and the inflammatory index to predict fewer mathematicalerrors (pvalues of .036 and .023). Interactions with folate (pvalues of .016and .006) and C-reactive protein (pvalues ranging from
Conclusions: In this dataset, representative of the US population, inflamma-tion and folate concentrations moderated but did not mediate the associationbetweenH. pyloriseropositivity and cognition.
BYU ScholarsArchive Citation
Brown, Bruce L.; Berrett, Andrew N.; Gale, Shawn D.; Erickson, Lance D.; and Hedges, Dawson W., "Folate and Inflammatory Markers Moderate the Association Between Helicobacter pylori Exposure and Cognitive Function in US Adults" (2016). Faculty Publications. 5988.
https://scholarsarchive.byu.edu/facpub/5988
Document Type
Peer-Reviewed Article
Publication Date
2016
Permanent URL
http://hdl.lib.byu.edu/1877/8717
Publisher
John Wiley & Sons Ltd
Language
English
College
Family, Home, and Social Sciences
Department
Psychology