Keywords

pharmacogenomics, amino acid properties, SNP evaluation

Abstract

Each year people suffer from complications of adverse drug reactions, but with pharmacogenomics there is hope to prevent thousands of these people from suffering or dying needlessly. The CYP2D6 gene is responsible for metabolizing a large portion of these drugs. Because of the gene’s importance, various approaches have been taken to analyze CYP2D6 and single nucleotide polymorphisms (SNPs) throughout its sequence. This study introduces a novel method to analyze the effects of SNPs on encoded protein complexes by focusing on the biochemical properties of each nonsynonymous substitution using the program TreeSAAP. We apply this technique to SNPs found in the CYP2D6 gene. Our results show four SNPs that exhibit radical changes in amino acid properties which may cause a lack of functionality in the CYP2D 6 gene and contribute to a person’s inability to metabolize specific drugs.

Original Publication Citation

Pharmacogenomics: Analyzing SNPs in the CYP2D6 Gene Using Amino Acid Properties, Mark Ebbert, Timothy OConnor, Wesley Beckstead, Mark Clement, David McClellan, Biotechnology and Bioinformatics Symposium(BIOT), Provo, Utah, October 26, pp 1-5