Noise Analysis and Sensitivity Enhancement in Immunomagnetic Nanomechanical Biosensors
Keywords
noise analysis, immunomagnetic nanomechanical biosensors
Abstract
We report noise and detection limitations in cantilever-based immunomagnetic biosensors. A differential cantilever system with sensing and control arms was used whereby the control arm was passivated with bovine serum albumin (BSA) and the sensing arm was functionalized with biotin-BSA. Streptavidin-coated magnetic beads were exposed to cantilever arms. An oscillatory magnetic field induced a magnetic force on the beads which caused a relative deflection of the sensing arm. Increasing the excitation frequency suppressed the 1/f noise by 100-fold, resulting in a deflection resolution of 0.065Å in air.
Original Publication Citation
Icoz, Kutay and Iverson, Brian D. and Savran, Cagri. Noise analysis and sensitivity enhancement in immunomagnetic nanomechanical biosensors. Applied Physics Letters, 93, 103902 (2008).
BYU ScholarsArchive Citation
Icoz, Kutay; Iverson, Brian D.; and Savran, Cagri, "Noise Analysis and Sensitivity Enhancement in Immunomagnetic Nanomechanical Biosensors" (2008). Faculty Publications. 1588.
https://scholarsarchive.byu.edu/facpub/1588
Document Type
Peer-Reviewed Article
Publication Date
2008
Permanent URL
http://hdl.lib.byu.edu/1877/3504
Publisher
Applied Physics Letters
Language
English
College
Ira A. Fulton College of Engineering and Technology
Department
Mechanical Engineering
Copyright Status
The publisher's final version can be accessed at http://scitation.aip.org/content/aip/journal/apl/93/10/10.1063/1.2980036.
Copyright Use Information
http://lib.byu.edu/about/copyright/