Abstract
Quinazoline and phthalazine were hydrogenated at low pressure and temperature (60 psi, room temperature) and high pressure and temperature (2000 psi, 100°C, 150°C} in neutral and acidic solvents over 5% Pd/C, 5% Ru/C, 5% Rh/Al2O3 , 5% Rh/C, and 5% Pt/C. Chromatographic methods for determining the qualitative and quantitative composition of hydrogenation mixtures were developed. The compositions of quinazoline and phthalazine-hydrogenation mixtures were determined. Eight phthalazine-hydrogenation products were detected and isolated: (1) 1,2-dihydrophthalazine, (2) 1,2,3,4-tetrahydrophthalazine, (3) a,a'-diamino-o-xylene, (4) o-methylbenzylamine, (5) 1,3-dihydroisoindole, (6) o-xylene, (7 and 8) cis- and trans- 1,2-dimethylcyclohexane. These products were identified by isolating them from reaction mixtures and comparing their ir, nmr, and mass spectra with those of authentic samples. Pathways of hydrogenation were proposed for both quinazoline and phthalazine, and evidence for each pathway was presented.
Degree
PhD
College and Department
Physical and Mathematical Sciences; Chemistry and Biochemistry
Rights
http://lib.byu.edu/about/copyright/
BYU ScholarsArchive Citation
Elder, Danny Lee, "The catalytic hydrogenation of benzodiazines.|nI.|pPhthlazine.|nII.|pQuinazoline" (1969). Theses and Dissertations. 8206.
https://scholarsarchive.byu.edu/etd/8206
Date Submitted
1969-08-01
Document Type
Dissertation
Handle
http://hdl.lib.byu.edu/1877/Letd553
Keywords
Hydrogenation, Benzodiazines
Language
English