Abstract

Cortical gyrification is essential for cognitive development, yet its relationship with executive functioning (EF) in pediatric traumatic brain injury (TBI) remains unclear. This study examined whether children with TBI exhibit atypical cortical folding in EF-related regions and whether these differences relate to EF performance. Using FreeSurfer 7.1.1, we analyzed local gyrification index (LGI) in 206 participants (ages 5-18) from 14 sites within the ENIGMA Pediatric msTBI Working Group. Vertex-wise regression revealed that longer time since injury (TSI) was associated with increased gyrification in the right fusiform gyrus and multiple left-hemisphere regions, suggesting region-specific neuroplasticity. Contrary to expectations, higher GCS scores (milder injuries) correlated with greater gyrification, possibly reflecting compensatory mechanisms. No significant LGI-EF relationship was observed, highlighting the need for multimodal imaging to further explore neurodevelopmental outcomes in pediatric TBI.

Degree

College and Department

Family, Home, and Social Sciences; Psychology

Rights

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