Abstract
Human Immunodeficiency Virus (HIV-1) is the causative agent for acquired immunodeficiency syndrome (AIDS). Different strains of HIV-1 have been linked to a long term non-progressor (LTNP) or rapid progressor (RP) form of disease depending on rate of AIDS progression. Viral protein R (Vpr) is a viral protein that has been linked to varying rates of AIDS progression depending on the sequence. In this work, the effects of two polymorphisms, a LTNP and a RP, on different cells are studied. The LTNP virus was linked to lower release of pro-inflammatory cytokines, such as TNF and IL-6, and an increase in apoptotic cell death. Pro-inflammatory genes, such as ULBP2 and ICAM1, were seen to be downregulated in the LTNP virus when compared to the Wild Type virus. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) caused a pandemic in 2020, resulting in a shortage of disinfectants. Neutralizers that can be used to more effectively test disinfectants were formulated and used to show effective disinfection of two disinfectants.
Degree
MS
College and Department
Life Sciences; Microbiology and Molecular Biology
Rights
https://lib.byu.edu/about/copyright/
BYU ScholarsArchive Citation
Lopez, J. Brandon, "Connecting HIV-1 Viral Protein R Polymorphisms to Changes in Inflammatory Signals and Efficacy Testing of Essential Oils as Disinfectants Against SARS-CoV-2" (2024). Theses and Dissertations. 10559.
https://scholarsarchive.byu.edu/etd/10559
Date Submitted
2024-08-07
Document Type
Thesis
Handle
http://hdl.lib.byu.edu/1877/etd13397
Keywords
AIDS, HIV-1, Vpr, SARS-CoV-2, apoptosis, inflammation
Language
english