Keywords

Cystic Fibrosis, Ecological Review, Ecology, Further Study

Abstract

This article focuses on the mechanisms of cystic fibrosis and the resulting microbial dysbiosis created through this disease. Through mutations in the CFTR gene, chloride ion proteins become dysfunctional, and mucus secreted in the lungs become thick and heavy, allowing infectious and pathogenic bacteria to thrive. 16s rRNA has been the primary method of sequencing the lung microbiome. Researchers have relied on bronchoscopies to collect proper samples. It can be concluded through current research that chloride ion dysfunction allows for an abnormal lung environment to develop. This abnormal environment allows for chronic infection of the lungs, and the formation of biofilms that would otherwise not be developed. The bacteria that can thrive in this abnormal environment cause a wide range of issues in cystic fibrosis patients, which ultimately leads to early mortality. A greater understanding of the microbiome of cystic fibrosis affected lungs gives a greater insight of the issues that cystic fibrosis presents.