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Keywords
Cancer, FFPE vs Cryo, personalized medicine
Abstract
It is a fact that personalized cancer treatment leads to better patient outcomes. But what if the current treatments aren't as personalized as they could be?
Clinical cancer tissue samples are typically sent to labs as formalin-fixed and paraffin-embedded (FFPE) tissues. A recent study4 indicates that cryo-preserved (CP) tissues offer significantly better DNA quality and quantity than FFPE samples, suggesting a need to reevaluate preservation methods. We aim to expand this research by comparing protein expression in FFPE and CP samples.
Specifically, we will focus on PD-L1, a protein that inhibits T-cells and is overexpressed in all cancer cells. The quantity of PD-L1 is crucial for identifying cancer in tissue, making it an ideal candidate for our comparison.
Hypothesis: CP tissue samples will yield higher amounts of PD-L1 compared to FFPE preserved tissue samples.
BYU ScholarsArchive Citation
Bascom, Rebecca; Nelson, Paige; Harris, Jacob; Davis, Jack; BUrr, Mackenzie; Okojie, Jeffrey; Booker, David; Dixon, Ken; and Barrott, Jared, "Chilling Insights: A Comparative Study of Cancer Tissue Preservation" (2025). Library/Life Sciences Undergraduate Poster Competition 2025. 69.
https://scholarsarchive.byu.edu/library_studentposters_2025/69
Document Type
Article
Publication Date
2025
Language
English
College
Life Sciences
Department
Cell Biology and Physiology
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