End Epilepsy: Human and Rodent Seizures Demonstrate a Dynamic Interplay with Spreading Depolarizations

Authors

Daniel Hummel, Brigham Young UniversityFollow
Jacob H. Norby, Brigham Young University
Noah Ricks, Brigham Young University
John D. Rolston, Harvard Medical School
Shervin Rahimpour, University of Utah
Juha Voipio, University of Helsinki
Andrew J. Trevelyan, Newcastle University Biosciences Institute
Elliot H. Smith, University of Utah
Ryley Parrish, Brigham Young University - ProvoFollow

Files

Keywords

Seizure, Spreading Depolarization, Rodent, Human, Termination

Abstract

Affecting more than 50 million people worldwide, Epilepsy is a condition of repeated seizures. Seizures (Sz) occur when brain cells transmit uncontrolled electrical signals, and most often terminate on their own, but how this happens is unknown. A proposed mechanism of Sz termination is a spreading depolarization (SD). A SD is a wave that travels through the brain, suppressing brain activity. Currently, the relationship between SDs and seizures is not well understood. The goal of this study was to understand how the two phenomena interact in both rodent brains, and humans. Better understanding of SDs may lead to the development of novel treatments for Epilepsy.

BYU ScholarsArchive Citation

Hummel, Daniel; Norby, Jacob H.; Ricks, Noah; Rolston, John D.; Rahimpour, Shervin; Voipio, Juha; Trevelyan, Andrew J.; Smith, Elliot H.; and Parrish, Ryley, "End Epilepsy: Human and Rodent Seizures Demonstrate a Dynamic Interplay with Spreading Depolarizations" (2025). Library/Life Sciences Undergraduate Poster Competition 2025. 55.
https://scholarsarchive.byu.edu/library_studentposters_2025/55

Document Type

Article

Publication Date

2025

Language

English

College

Life Sciences

Department

Cell Biology and Physiology

University Standing at Time of Publication

Freshman

Copyright Use Information

https://lib.byu.edu/about/copyright/