ZMP-Induced Activation of AMPK Enhances Accumbal Dopamine Function

Authors

Isabella Roque, Brigham Young University - ProvoFollow
Jordan Yorgason, Brigham Young University - ProvoFollow
Rachel Campbell, Brigham Young University - Provo
Serin Baker, Brigham Young University - Provo
Jared McFarlane, Brigham Young University - Provo
Oliver Saunders, Brigham Young University - Provo
David Thomson, Brigham Young University - Provo

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Keywords

p39, dopamine release, ZMP, CIN firing

Abstract

Oral Presentation Honorable Mention

• Dopamine terminal function is associated with motivation

• Fasting activates AMPK, a cellular sensor that measures intracellular AMP relative to ATP

• AMPK activation is a target of interest for age related cognitive decline, prevention of muscle wasting, etc.

• ZMP is an endogenous nucleotide AMP mimetic that activates AMPK

• The present study examined the novel precursor ZMP compound called P39 using an ex vivo mouse model

BYU ScholarsArchive Citation

Roque, Isabella; Yorgason, Jordan; Campbell, Rachel; Baker, Serin; McFarlane, Jared; Saunders, Oliver; and Thomson, David, "ZMP-Induced Activation of AMPK Enhances Accumbal Dopamine Function" (2024). Library/Life Sciences Undergraduate Poster Competition 2024. 6.
https://scholarsarchive.byu.edu/library_studentposters_2024/6

Document Type

Poster

Publication Date

2024-03-21

Language

English

College

Life Sciences

Department

Cell Biology and Physiology

University Standing at Time of Publication

Senior

Copyright Use Information

https://lib.byu.edu/about/copyright/