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Keywords

ADHD medication is more potent and effective during ovulation

Abstract

• Women escalate psychostimulant abuse more quickly than men. Women who are prescribed psychostimulants for ADHD report fluctuations in drug efficacy that correspond to their menstrual cycle.

• In rodents, females acquire psychostimulant addiction more readily and release more dopamine (DA) in the dorsal striatum, an effect mediated by estrogen.

• However, the impact of the estrous cycle in the nucleus accumbens (NAc), a core region for learning and addiction in the ventral striatum, is underexplored.

• Here, we examine cocaine, methylphenidate (Ritalin), and methamphetamine (Desoxyn) effects on DA transmission in male and naturally-cycling female mice.

Document Type

Poster

Publication Date

2024-03-21

Language

English

College

Life Sciences

Department

Neuroscience

University Standing at Time of Publication

Senior

ADHD medication is more potent and effective during ovulation

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