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Keywords
Dopamine Release, Ivermectin, Dorsal Striatum, Parkinson's disease
Abstract
• The substantia nigra compacta releases dopamine into the dorsal striatum, a brain region associated with movement and motivation
• Cholinergic interneurons in the dorsal striatum can directly cause dopamine release
• IVM is a known positive allosteric modulator of P2X4 receptors as well as nicotinic
• acetylcholine receptors
• Ivermectin is known to affect many dopamine linked behaviors, but no studies have been conducted to determine if Ivermectin is able to modulate dopamine release
BYU ScholarsArchive Citation
Love, Tyler; Yorgason, Jordan; Wadsworth, Hillary; Warnecke, Alicia; Barlow, Joshua; Steimle, Emma; Ronström, Joakim; Williams, Pacen; Galbraith, Christopher; Baldridge, Jared; Jakowec, Michael; and Davies, Daryl, "Ivermectin Activates Striatal Cholinergic Interneurons to Enhance Dopamine Release" (2024). Library/Life Sciences Undergraduate Poster Competition 2024. 28.
https://scholarsarchive.byu.edu/library_studentposters_2024/28
Document Type
Poster
Publication Date
2024-03-21
Language
English
College
Life Sciences
Department
Cell Biology and Physiology
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