Title
Changes to Morphine Sensitivity in the Ventral Tegmental Area after Morphine Conditioning
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Keywords
Sex effect, Morphine, FSCV, Mu, Kappa, Delta
Abstract
Dopamine circuit function in ventral tegmental area (VTA) is implicated in the reinforcing effects of drugs of abuse including opioids.
Morphine is known to activate three receptors: mu (MORs), delta (DORs) and kappa (KORs). Although the mu receptor is considered the main receptor in the addiction pathway, in vivo administration of both mu and delta agonists has shown behavior characteristic of addiction. In contrast, kappa agonists have been shown to be aversive to mice.
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BYU ScholarsArchive Citation
Hafen, Caylor W.; Treanor, C. J.; Flora, P. D.; Jones, G. C.; Otteson, D. Z.; Bishop, S.; Breibholt, J.; Ahrens, C.; Rounkles, J.; Saunders, C.; Wadsworth, H. A.; and Yorgason, J. T., "Changes to Morphine Sensitivity in the Ventral Tegmental Area after Morphine Conditioning" (2023). Library/Life Sciences Undergraduate Poster Competition 2023. 64.
https://scholarsarchive.byu.edu/library_studentposters_2023/64
Document Type
Video
Publication Date
2023-02-27
Language
English
College
Life Sciences
Department
Neuroscience
Copyright Use Information
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