Effects of immune system activity and methamphetamine on dopamine terminal function

Title

Effects of immune system activity and methamphetamine on dopamine terminal function

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Keywords

Addiction, microglia, dopamine, nucleus accumbens, 2-photon imaging

Abstract

1st place video

Microglia are CNS macrophages that act as the immune system of the brain.

Lipopolysaccharides (LPS) are bacteria-derived endotoxins that trigger immune response, including microglial activation.

Behavioral data shows that LPS-induced microglial activation heightens drug reward and dependence (conditioned place preference and locomotor activity).

Present study examines how activated microglia modulate dopamine terminal function in the absence and presence of methamphetamine (Meth).

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Document Type

Poster

Publication Date

2023-02-27

Language

English

College

J. Reuben Clark Law School

Department

Neuroscience

University Standing at Time of Publication

Senior

Effects of immune system activity and methamphetamine on dopamine terminal function

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