Effects of immune system activity and methamphetamine on dopamine terminal function

Authors

Lauren Ford, Brigham Young University - ProvoFollow
Sara Linderman, Brigham Young University - Provo
Hillary Wadsworth, Brigham Young University - Provo
Jordan Yorgason, Brigham Young University - Provo

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Keywords

immune system, microglia, methamphetamine, dopamine, FSCV

Abstract

• Dopamine (DA) release in the nucleus accumbens (NAc) is associated with addiction and reward • Microglia are native macrophages that act as the immune system of the brain
• Lipopolysaccharides (LPS) are bacteria-derived endotoxins that trigger an immune response through microglial activation
• The dopaminergic drug methamphetamine can also target microglia, but produces feelings of reward rather than feelings of sickness
• Present study examines the modulatory effect of microglial activation on dopamine terminal function in the presence of methamphetamine

BYU ScholarsArchive Citation

Ford, Lauren; Linderman, Sara; Wadsworth, Hillary; and Yorgason, Jordan, "Effects of immune system activity and methamphetamine on dopamine terminal function" (2022). Library/Life Sciences Undergraduate Poster Competition 2022. 38.
https://scholarsarchive.byu.edu/library_studentposters_2022/38

Document Type

Poster

Publication Date

2022-3

Language

English

College

Life Sciences

Department

Neuroscience

University Standing at Time of Publication

Senior

Copyright Use Information

https://lib.byu.edu/about/copyright/