Estradiol effects on dopamine release and cholinergic interactions

Title

Estradiol effects on dopamine release and cholinergic interactions

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Keywords

Neurons, neuroscience, dopamine, estradiol

Abstract

Dopamine release in the striatum is regulated by intrinsic activity as well as local cholinergic interneurons. Dopamine terminals express nicotinic acetylcholine receptors (nAChR), including a4~2 receptors that are sensitive to sex hormones. These receptors are also activated by acetylcholine release from cholinergic interneutons that is sufficient for driving dopamine relelase independent on dopamine somatic firing. The present study examines cholinergic mediated dopamine release and the sex hormone estradiol.

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Document Type

Poster

Publication Date

2022-3

Language

English

College

Life Sciences

Department

Cell Biology and Physiology

University Standing at Time of Publication

Senior

Estradiol effects on dopamine release and cholinergic interactions

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