Epigenetic Profiling of Human Peripheral Blood Monocytes
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Epigenentics, ATAC-seq, Innate Immunity, Adaptive Immunity, Chromatin
Identifying the epigenetic mechanisms at play within cell-types is one of the early steps in understanding crucial differences between healthy and diseased cells. Peripheral blood monocytes play a crucial role in both the innate and adaptive immune system. We explore differences that exists within the epigenetic profiles of human monocytes based on sex. To determine if chromatin accessibility is sexually dimorphic, we collected blood samples from 6 volunteer adults (3 men and 3 women). Monocytes were then isolated from each volunteer. The ATAC-seq protocol was followed, and data analysis was performed. The results of this analysis will determine to what extent chromatin accessibility of human monocytes is impacted by sex. These differences could have implications for therapeutics targeting the immune system.
BYU ScholarsArchive Citation
Cole, Nolan; Adams, Kevin; and Johnson, Steven M. Ph.D., "Epigenetic Profiling of Human Peripheral Blood Monocytes" (2021). Library/Life Sciences Undergraduate Poster Competition 2021. 23.
Microbiology and Molecular Biology
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