BYU ScholarsArchive

Title

Epigenetic Profiling of Human Peripheral Blood Monocytes

Authors

Nolan Cole, Brigham Young University - ProvoFollow
Kevin Adams, Brigham Young University - Provo
Steven M. Johnson Ph.D., Brigham Young University - ProvoFollow

Files

Keywords

Epigenentics, ATAC-seq, Innate Immunity, Adaptive Immunity, Chromatin

Abstract

Identifying the epigenetic mechanisms at play within cell-types is one of the early steps in understanding crucial differences between healthy and diseased cells. Peripheral blood monocytes play a crucial role in both the innate and adaptive immune system. We explore differences that exists within the epigenetic profiles of human monocytes based on sex. To determine if chromatin accessibility is sexually dimorphic, we collected blood samples from 6 volunteer adults (3 men and 3 women). Monocytes were then isolated from each volunteer. The ATAC-seq protocol was followed, and data analysis was performed. The results of this analysis will determine to what extent chromatin accessibility of human monocytes is impacted by sex. These differences could have implications for therapeutics targeting the immune system.

BYU ScholarsArchive Citation

Cole, Nolan; Adams, Kevin; and Johnson, Steven M. Ph.D., "Epigenetic Profiling of Human Peripheral Blood Monocytes" (2021). Library/Life Sciences Undergraduate Poster Competition 2021. 23.
https://scholarsarchive.byu.edu/library_studentposters_2021/23

Document Type

Video

Publication Date

2021

Language

English

College

Life Sciences

Department

Microbiology and Molecular Biology

University Standing at Time of Publication

Junior

Copyright Use Information

http://lib.byu.edu/about/copyright/