patient outcome assessment, exercise tests, muscle strength, functional status, anthropometry


Objective: To inform selection of physical measures for studies of ARDS survivors within 12 months of ARDS Methods: Secondary analysis of data from 6-month survivors participating in a U.S. multicenter prospective study (ARDSNet Long-Term Outcome Study [ALTOS], N=134) or a multi-site prospective study in Baltimore, MD (Improving Care of Acute Lung Injury Patients [ICAP], N=99). Physical measures, assessed at 6-month follow-up, were categorized according to the World HealthOrganization’s International Classification of Disability and Health: body functions and structures, activity, and participation. Patient-centered outcomes were evaluated at 6 and 12- months: survival, hospitalization, alive at home status, and health-related quality of life. Pearson correlation, linear and logistic regression models were used to quantify associations of physical measures with patient-centered outcomes.

Main Results: No 6-month body functions and structures measure demonstrated consistent association with 6- or 12-month outcomes in multivariable regression. The 6-minute walk test, an activity measure, was associated with 6-month SF-36 physical component scores (PCS, beta range: 0.99 to 1.52, p

Conclusions: Participation measures better reflect patient quality-of-life than measures of body functions and structures within 12 months of ARDS among 6-month survivors, and are recommended for inclusion as a core measure in future studies.

Original Publication Citation

Thorax. 2017 October ; 72(10): 884–892. doi:10.1136/thoraxjnl-2016-209400

Document Type

Peer-Reviewed Article

Publication Date







Family, Home, and Social Sciences



University Standing at Time of Publication

Full Professor

Included in

Psychology Commons