sodium flux, voltage clamped, squid giant axons, loligo pealei
The sodium flux ratio across the axolemma of internally perfused, voltage-clamped giant axons of Loligo pealei has been measured at various membrane potentials. The flux ratio exponent obtained from these measurements was about unity and independent of membrane voltage over the 50 mV range from about -20 to +30 mV. These results, combined with previous measurements of ion permeation through sodium channels, show that the sodium channel behaves like a multi-ion pore with two ion binding sites that are rarely simultaneously occupied by sodium.
Original Publication Citation
Begenisich, T. and D. Busath. 1981. Sodium flux ratio in voltage-clamped squid giant axons. Journal of General Physiology 77:489-502.
BYU ScholarsArchive Citation
Busath, David D. and Begenisich, Ted, "Sodium Flux Ratio in Voltage-Clamped Squid Giant Axons" (1981). All Faculty Publications. 1360.
University of Rochester School of Medicine and Dentistry
Physiology and Developmental Biology
From the Department of Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642. D. Busath's present address is the Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77550.
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