Transient Receptor Potential channels (TRP) are a superfamily of cationic specific ionchannels that are regulated by various stimuli such as temperature, pH, mechanical stress, ligandsand ion concentration. The role of TRP channels in disease states such as autosomal dominantpolycystic kidney disease, cancer metastasis, and developmental defects lend credence to thebelief that they play an important part in epithelial morphogenesis events. The development ofsomites, neural tube closure and migration of neural crest cells to form things such as the faceand heart is a good developmental model for the aforementioned cellular processes. We haveshown that TRP channels can be found in the developing ectoderm, hindbrain, and heart and thatthe inhibition of TRP channels in a developing embryo results in phenotypes suggestingperturbation of cellular remodeling processes. This leads to the question of the specific role ofTRP channels in the epithelial mesenchymal transition and remodeling in developing chickembryos.
College and Department
Life Sciences; Physiology and Developmental Biology
BYU ScholarsArchive Citation
Waddell, Trinity Q., "Role of Transient Receptor Potential Channels in Epithelial Morphogenesis in Chick Embryo" (2019). Theses and Dissertations. 8112.
EMT, TRP, development, epithelial morphogenesis, epithelial rearrangement, chick, gallus gallus, neural tube, heart