Serotonin (5-hydroxytryptamine, 5-HT), considered to be a synaptic transmitter within the central nervous system, has been shown to be localized mainly in the paleocortex of the brain. Others have shown disturbances of normal 5-HT metabolism to be associated with mental illness and disease. Attempts to inject tritium labelled 5-HT into cerebrospinal fluid of the rat brain for anatomical localization studies were·made. The following observations were noted, (1) there exists a perivascular space in which fluid flows and distribution is relatively uninhibited as compared to subarachnoid space, (2) the labelled 5-HT penetration of brain tissue parenchyma is restricted and radioactivity is attenuated going away from the surface of access, and (3) the injected labelled 5-HT is absorbed into areas believed to contain true serotonergic fibers, especially throughout the paleocortex. Suggestions concerning the anatomical importance of the perivascular space observed are made. Also comparisons of 5-HT brain localization with metabolism and physiology of 5-HT are made in relation to mental illness.
College and Department
Plant and Wildlife Sciences
BYU ScholarsArchive Citation
Wagstaff, Brent D., "Autoradiographic studies of the distribution of serotonin in the rat brain" (1971). Theses and Dissertations. 7912.
Serotonin; Rats; Brain