We demonstrate the success of recurrent neural networks in gene network inference and expression prediction using a hybrid of particle swarm optimization and differential evolution to overcome the classic obstacle of local minima in training recurrent neural networks. We also provide an improved validation framework for the evaluation of genetic network modeling systems that will result in better generalization and long-term prediction capability. Success in the modeling of gene regulation and prediction of gene expression will lead to more rapid discovery and development of therapeutic medicine, earlier diagnosis and treatment of adverse conditions, and vast advancements in life science research.
College and Department
Physical and Mathematical Sciences; Computer Science
BYU ScholarsArchive Citation
Chan, Heather Y., "Gene Network Inference and Expression Prediction Using Recurrent Neural Networks and Evolutionary Algorithms" (2010). All Theses and Dissertations. 2648.
genetic network modeling, gene network inference, gene expression prediction, recurrent networks, evolutionary algorithms, time series prediction