Modeling the hydrolyzing action of secretory phospholipase A2 with ordinary differential equations and Monte Carlo Methods
Although cell membranes normally resist the hydrolysis of secretory phospholipase A2, a series of current investigations demonstrated that the changes in lipid order caused by increased calcium has a relationship with the susceptibility to phospholipase A2. To further explore this relationship, we setup ordinary differential equations models, statistic models and stochastic models to compare the response of human erythrocytes to the hydrolyzing action of secretory phospholipase A2 and the relationship between the susceptibility of hydrolysis and the physical properties of secretory phospholipase A2. Furthermore, we use models to determine the ability of calcium ionophore to increased membrane susceptibility.
College and Department
Physical and Mathematical Sciences; Mathematics
BYU ScholarsArchive Citation
Dozier, Zijun Lan, "Modeling the hydrolyzing action of secretory phospholipase A2 with ordinary differential equations and Monte Carlo Methods" (2008). Theses and Dissertations. 1387.
phospholipase A2, membrane susceptibility, Monte Carlo