Keywords
primary insomnia, sleep restriction, fluorodeoxyglucose, positron emission tomography, FDG, PET, neuroimaging, quantitative EEG
Abstract
Background: Restricting time in bed improves insomnia symptoms, but the neural mechanisms for this effect are unknown. Total and partial acute sleep restriction may be useful paradigms for elucidating these effects. We examined the impact of acute sleep restriction on cerebral glucose metabolism during non-rapid eye movement (NREM) sleep in individuals with primary insomnia (PI; n=17) and good sleep (GS; n=19).
Methods: Participants underwent [18F]fluorodeoxyglucose positron emission tomography (FDGPET) scans during baseline and recovery NREM sleep following one night of partial or total sleep restriction. We compared group differences (PI vs. GS) in baseline-recovery changes, as well as main effects of group and condition (baseline vs. recovery NREM sleep), for relative regional cerebral metabolic rate for glucose (rCMRglc), whole-brain glucose metabolism, and sleep quality.
Results: Relative rCMRglc was significantly lower during recovery NREM sleep compared to baseline NREM sleep in the left frontoparietal cortex, medial frontal cortex, posterior cingulate cortex, and thalamus, with no significant group differences. GS, but not PI, had lower whole-brain glucose metabolism during recovery NREM sleep compared to baseline. Acute sleep restriction
Original Publication Citation
Kay DK, Karim HT, Hasler BP, James JA, Germain A, Hall MH, Franzen, PL, Price J, Nofzinger EA, Buysse DJ. Impact of acute sleep restriction on cerebral glucose metabolism during recovery non-rapid eye movement sleep among individuals with primary insomnia and good sleeper controls. Sleep Med. 2019; 55:81-91. doi: 10.1016/j.sleep.2018.12.007
BYU ScholarsArchive Citation
Kay, Daniel; Karim, Helmet T.; Hasle, Brant P.; James, Jeffrey A.; Germain, Anne; Hall, Martica H.; Franzen, Peter L.; Price, Julie C.; Nofzinger, Eric A.; and Buysse, Daniel J., "Impact of Acute Sleep Restriction on Cerebral Glucose Metabolism during Recovery Non-Rapid Eye Movement Sleep among Individuals with Primary Insomnia and Good Sleeper Controls" (2019). Faculty Publications. 6475.
https://scholarsarchive.byu.edu/facpub/6475
Document Type
Peer-Reviewed Article
Publication Date
2019-3
Permanent URL
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8232888/
Publisher
Sleep Med.
Language
English
College
Family, Home, and Social Sciences
Department
Psychology
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