Abstract

Although cell membranes normally resist the hydrolysis of secretory phospholipase A2, a series of current investigations demonstrated that the changes in lipid order caused by increased calcium has a relationship with the susceptibility to phospholipase A2. To further explore this relationship, we setup ordinary differential equations models, statistic models and stochastic models to compare the response of human erythrocytes to the hydrolyzing action of secretory phospholipase A2 and the relationship between the susceptibility of hydrolysis and the physical properties of secretory phospholipase A2. Furthermore, we use models to determine the ability of calcium ionophore to increased membrane susceptibility.

Degree

MS

College and Department

Physical and Mathematical Sciences; Mathematics

Rights

http://lib.byu.edu/about/copyright/

Date Submitted

2008-05-23

Document Type

Thesis

Handle

http://hdl.lib.byu.edu/1877/etd2398

Keywords

phospholipase A2, membrane susceptibility, Monte Carlo

Included in

Mathematics Commons

Share

COinS