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COVID-19, Sequencing, Local Community, Wastewater, Timeline
The global COVID-19 pandemic has led to an urgent need for scalable methods for clinical diagnostics and tracking of virus variants. In this paper, we attempted a novel method of sequencing using Large Reverse Transcriptase-based cloning (LRTC). Although our methodology ended up not working due to high amount and fast degradation of RNA, we were able to sequence multiple variants of COVID-19 Positive samples from the BYU Student Health Center and 4 sewage samples to check for variant outbreaks in corresponding times. We were able to find several corresponding variants and track the progression of mutation in our local population.
BYU ScholarsArchive Citation
Purnell, Madelyn, "Sequencing the Guts out of COVID-19; The Evolution Behind the COVID-19 Pandemic" (2022). Undergraduate Honors Theses. 262.