First Faculty Advisor
Dr. Scott Steffensen
First Faculty Reader
Dr. Jordan Yorgason
Dr. Rebekka Matheson
catharanthine, dopamine, alcohol, addiction
This thesis discusses the history of catharanthine and related compounds, and their potential anti-addictive properties. Current research is exploring possible mechanisms of these properties. Past studies have found catharanthine has effects on neurons that project to the mesocorticolimbic system, an area implicated in addiction. We have seen that catharanthine decreases evoked dopamine (DA) release but increases basal DA release. This is the first study to investigate catharanthine’s effect on DA transmission in vivo. Using microdialysis, we determined the effect of catharanthine on DA in the nucleus accumbens of the striatum. This study determines the effect of different doses of catharanthine, kinetics of catharanthine, and the effect of catharanthine and ethanol injections. We also used the drink in the dark behavioral method to determine if catharanthine decreased drinking behavior in mice.
BYU ScholarsArchive Citation
Baldwin, Emily, "Effects of Catharanthine on Dopamine Release in the Nucleus Accumbens and Ethanol Consumption" (2021). Undergraduate Honors Theses. 242.