Degree Name

Department

Chemistry and Biochemistry

College

Physical and Mathematical Sciences

Defense Date

2021-06-08

Publication Date

2021-06-16

First Faculty Advisor

Dr. Steven L. Castle

First Faculty Reader

Dr. Joshua L. Price

Honors Coordinator

Dr. Wally F. Paxton

Keywords

synthesis, peptides, amino acids, α, β-dehydroamino acids

Abstract

This thesis explores the synthesis of fluorinated α,β-dehydroamino acids, specifically a fluorinated dehydrovaline derivative. Previous work has been done on the equivalent dehydrovaline derivative without fluorine present and this work builds toward the fluorinated version with the goal of comparing the two structurally. The synthesis presented here pulls from previous synthetic strategies employed for dehydrovaline while also exploring the synthetic impact of the electronegative fluorine atoms.